Enclomiphene citrate is a selective estrogen receptor modulator (SERM) — the trans-isomer of clomiphene citrate that specifically targets estrogen feedback in the hypothalamus to stimulate endogenous hormone pathways.
Unlike standard testosterone replacement therapy (TRT), enclomiphene doesn’t introduce external testosterone. Instead, it encourages the body’s own hormonal axis (hypothalamic-pituitary-gonadal axis) to produce more luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn increases natural testosterone production.
It’s frequently prescribed (or compounded) for:
Secondary hypogonadism (Low-T) in adult men
Maintaining fertility while increasing testosterone
Support during post-cycle therapy (PCT) for athletes or bodybuilders after anabolic steroid use
Enclomiphene is studied for several potential benefits:
Increases natural testosterone production by blocking estrogen feedback — leading to higher LH and FSH release.
Can improve testosterone levels without suppressing fertility, unlike many TRT options.
May preserve sperm production and testicular function while elevating testosterone.
Enhanced energy and mood
Increased libido and vitality
Possible improvements in muscle maintenance or body composition
Often used in post-cycle therapy to restart endocrine function after anabolic steroid or SARM use.
Side Effects
Commonly reported side effects include headache, nausea, mood swings, flushing, and dizziness — generally mild but can occur.
Enclomiphene citrate is a selective estrogen receptor modulator (SERM) — the trans-isomer of clomiphene citrate that specifically targets estrogen feedback in the hypothalamus to stimulate endogenous hormone pathways.
Unlike standard testosterone replacement therapy (TRT), enclomiphene doesn’t introduce external testosterone. Instead, it encourages the body’s own hormonal axis (hypothalamic-pituitary-gonadal axis) to produce more luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn increases natural testosterone production.
It’s frequently prescribed (or compounded) for:
Secondary hypogonadism (Low-T) in adult men
Maintaining fertility while increasing testosterone
Support during post-cycle therapy (PCT) for athletes or bodybuilders after anabolic steroid use
Enclomiphene is studied for several potential benefits:
Increases natural testosterone production by blocking estrogen feedback — leading to higher LH and FSH release.
Can improve testosterone levels without suppressing fertility, unlike many TRT options.
May preserve sperm production and testicular function while elevating testosterone.
Enhanced energy and mood
Increased libido and vitality
Possible improvements in muscle maintenance or body composition
Often used in post-cycle therapy to restart endocrine function after anabolic steroid or SARM use.
Side Effects
Commonly reported side effects include headache, nausea, mood swings, flushing, and dizziness — generally mild but can occur.
